Gene Regulation and Systems Biology,2016,10(Suppl 1):11-7.Ĩ. NEAT1 is required for survival of breast cancer cells through FUS and miR-548. Ke H#, Zhao L#, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L, Jiao B*. Mammary gland stem cells and their application in breast cancer. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Lv C, Li F, Li X, Tian Y, Zhang Y, Sheng X, Song Y, Meng Q, Yuan S, Luan L, Andl T, Feng X, Jiao B, Xu M, Plikus MV, Dai X, Lengner C, Cui W, Ren F, Shuai J, Millar SE, Yu Z*. Chromosome-wide gene dosage rebalance may benefit tumor progression. Zhang H#, Yang X#, Feng X, Xu H, Yang Q, Zou L, Yan M, Liu D, Su X, Jiao B*. Proceedings of the National Academy of Sciences of U S A. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. Ke H#, Zhao L#, Zhang H#, Feng X, Xu H, Hao J, Wang S, Yang Q, Zou L, Su X, Wang L, Wu C, Wang Y, Nie J, Jiao B*. Chen W#, Wang H#, Cheng M#, Ni L, Zou L, Yang Q, Cai X*, Jiao B*. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Wang S#, Ke H#, Zhang H, Ma Y, Ao L, Zou L, Yang Q, Zhu H, Nie J*, Wu C*, Jiao B*. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. This approach will also offer more comprehensive understanding on sex chromosome evolution by comparing patterns of XCI among different animals, such as tree shrews and macaques, in order to reveal the law of the evolution on X chromosome.ġ. We will focus on analyzing the impacts of XCI in breast and other nutrients organs through analyzing the function of XCI in adult and embryonic tissues by studying the XCI status of breast and placenta in mouse and other model organism. Recently, more and more evidence show that the mammary gland lactation is greatly regulated by epigenetic modification, such as transgenerational inheritance, which is closely linked to another important epigenetic mechanism-XCI in our previous publications. The roles of XCI in mammary gland development We will explore this field through comprehensive discussion of the roles of these lncRNAs in mammary gland development.ģ.
The mechanisms of lncRNAs have been proposed in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited. LncRNA is an RNA molecule longer than 200 nucleotides and not translated into a protein. The working models of lncRNA in breast development We will characterize functions of imprinted genes through approaches of DNA methylome, transcript some analysis and functional procedures in mice and other animals.Ģ. Researches show that imprinted genes play important roles in early embryonic development, adult tissues development, certain genetic diseases and tumors. Genomic imprinting is an epigenetic phenomenon by which certain genes can be expressed in a parent-of-origin-specific manner. The impact of imprinted genes on breast development The mechanisms and evolutionary significance of X chromosome inactivation (XCI) in development and evolution are his research focus.Ĥ/2013 now Principal investigator of Imprinting in Development and Evolution Group, Kunming Institute of Zoology, Chinese Academy of Sciencesġ0/2008 - 4/2013 Postdoctor in University of Massachusetts Medical Schoolĥ/2007 - 10/2008 Research Assistant in College of Traditional Chinese Medicine, The Chinese University of Hong Kongĩ/2003 - 3/2007 Doctor of Philosophy in Environmental Science, The Chinese University of Hong Kongĩ/2000 - 7/2003 Master of zoology, College of Life Sciences, Southwest Universityĩ/1996 - 7/2000 Bachelor, College of Life Sciences, Southwest Universityġ. His research team is mainly interested in regulating mammary gland stem cells by imprinted genes and long non-coding RNA (lncRNA). Principal Investigator, joined Kunming Institute of Zoology, Chinese Academy of Sciences since July of 2013.
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